[Health] OSA & SUDDEN DEATH

[srlevine1]

Before you decide to stop therapy...

Sudden death in individuals with obstructive sleep apnoea: a systematic review and meta-analysis 

Objectives Over 1 billion individuals worldwide experience some form of sleep apnoea, and this number is steadily rising. Obstructive sleep apnoea (OSA) can negatively influence one’s quality of life and potentially increase mortality risk. However, the association between OSA and mortality has not been reliably estimated. This meta-analysis estimates the risk of all-cause and cardiovascular mortality in individuals with OSA.

Results We identified 22 observational studies (n=42 099 participants). The mean age was 62 years and 64% were men. OSA was associated with all-cause sudden death (RR=1.74, 95% CI: 1.44 to 2.10, I2=72%) and cardiovascular mortality (RR=1.94, 95% CI: 1.39 to 2.70, I2=32%). A marginally significant dose–response relationship between severity of OSA and the risk of death was observed (p for interaction=0.05): mild OSA (RR=1.16, 95% CI: 0.70 to 1.93), moderate OSA (RR=1.72, 95% CI: 1.11 to 2.67) and severe OSA (RR=2.87, 95% CI: 1.70 to 4.85). Meta-regression analysis showed that older age was a significant contributing factor in the relationship between OSA and mortality. The median study methodological quality was considered high.

Conclusions OSA is a significant risk factor for all-cause mortality and cardiac mortality. Prevention and treatment strategies to optimise survival and quality of life in individuals with OSA are urgently needed.

The study’s findings indicate that OSA is associated with several cardiovascular comorbidities, including hypertension, coronary artery disease, and congestive heart failure. Patients with OSA experience oxidative stress, or a lack of available oxygen to cells, which can contribute to an imbalance of antioxidants in the body. Over time, this imbalance damages cells and can speed up the aging process and lead to an array of health problems.

“Obstructive sleep apnea is a common condition that can have fatal consequences,” says coauthor John S. Oh, assistant professor in the surgery department at Penn State Health Milton S. Hershey Medical Center. “This is something that many patients do not consider when they are diagnosed with the condition, and our research will hopefully bring more attention to its prevention and treatment.”

“This study highlights the importance of appropriate prevention measures to reduce the incidence of OSA and OSA-related sudden death,” says coauthor Emily Heilbrunn. “Providing accessible and affordable treatments for populations with OSA may ultimately reduce adverse health outcomes for these individuals.”

https://news.psu.edu/story/664326/2021/0...conditions

Obstructive sleep apnea doubles risk of sudden death - Futurity

[2SleepBetta]

Yep. It's why I am driven by numbers far more than how I feel. Somehow most all my sleep was perceived as adequate rest until my PCP had me tested after a complaint about nocturia during a physical.

'Have all the following as listed above except for the last one, CHF. Not yet anyway, thank you Lord. I attribute them largely to simple untreated OSA and inspiratory flow limitations (IFL) and a snoring gene   : "OSA is associated with several cardiovascular comorbidities, including hypertension, coronary artery disease, and congestive heart failure."

My wife's occasional sharp elbow or "Jon roll over" wasn't enough for this dolt situated among male snorers much of my life. It was ignorance. No way my wife's fault; she was raised with a father who also snored notoriously. 

OSA is no joke.  I could easily have been treated. It erupted worse, it just had to be worse--because I don't think one could live that way--in prolonged OA's, long total times in apnea (TTIA) and high AHI all my first 6 weeks at 7 cm fixed (all that before finding and learning from AB).

[DaveCar]

Perhaps traffic accidents are in that OSA risk group too.
I uh know a guy who drove into a ditch and wrecked a vehicle. Luckily no one else was involved and he/she didn't suffer any long term effects.

[mesenteria]

With a little thinking from those who wonder about the matter, OSA leads to stress response, which tends to elevate cortisol semi-permanently. Hypertension is sure to follow, and probably weight gain, yet another contributor to early death.  The OSA may be in a chicken/egg paradox, but it it affects sleep, the heart, hormone imbalances, weight gain and metabolic syndrome, one would have to reason that controlling for OSA to the extent possible is going to have the grandparent around the grandkids a little longer.  That can't ever be a bad thing.